Radio

On January 30, 1950, Mutual Broadcasting System launched a radio adaptation, Mark Trail, featuring Matt Crowley in the title role. The 30-minute episodes aired three times weekly, and 174 episodes were produced, running until June 8, 1951. A second radio series, starring Staats Cotsworth, was broadcast on ABC beginning September 18, 1950, with 51 half-hour shows that ran thrice weekly until January, 1952. The series then switched to a 15-minute format, producing 125 episodes that aired weekdays through June 27, 1952. Only a handful of the 15-minute episodes are known to have survived.

The Minneapolis-St. Paul, public radio station KFAI hosted Mark Trail Radio Theatre starting in 1991. Produced by Babs Economon, its 17 adventures aired in 228 weekly installments on Friday evenings through September 2002.

In 1997, the National Oceanic and Atmospheric Administration (NOAA) began using Mark Trail as its official mascot, making him the voice of the National Weather Service and NOAA Weather and All Hazards Radio.