The FBI in Peace and War was a radio crime drama inspired by Frederick Lewis Collins' book, The FBI in Peace and War.

The idea for the show came from Louis Pelletier who wrote many of the scripts. Among the show's other writers were Jack Finke, Ed Adamson and Collins. It aired on CBS from November 25, 1944 to September 28, 1958, it had a variety of sponsors (including Lava Soap, Wildroot Cream-Oil, Lucky Strike, Nescafe and Wrigley's) over the years. In 1955 it was the eighth most popular show on radio, as noted in Time:

The Nielsen ratings of the top ten radio shows seemed to indicate that not much has changed in radio: 1) Jack Benny Show (CBA), 2) Amos 'n' Andy (CBS), 3) People Are Funny (NBC), 4) Our Miss Brooks (CBS) 5) Lux Radio Theater (NBC), 6) My Little Margie (CBS), 7) Dragnet (NBC), 8) FBI in Peace and War (CBS), 9) Bergen and McCarthy (CBS), 10) Groucho Marx (NBC).

Martin Blaine and Donald Briggs headed the cast. The theme was Prokofiev's The Love for Three Oranges.