The show aired first on CBS, October 7, 2940 - September 29, 1944. It then switched to NBC, October 3, 1944 - June 29, 1951.

Those appearing on the show were Lucille Wall as Portia Blake. Anne Seymour and Fran Carlon as Portia Blake during Wall's illness. Myron McCormick as Walter Manning (early 1940s). Robert Shayne As Walter Manning. Bartlett Robinson as Walter Manning for the last 8 years. Raymond Ives, Larry Robinson, Alastair Kyele, Skip Homeier and Edwin Bruce as Dickie Blake. Marjorie Anderson, Esther Ralston, Rosaline Greene, Selena Royle, Anne Seymour and Elizabeth Reller as Kathy Marsh. Richard Kendrick and Les Damon as Bill Baker. Nancy Douglass and Joan Banks as Arline Harrison Manning. Lesley Woods as Elaine Arden. Henrietta Tedro and Doris Rich as Miss Daisy. Carlton Young as Kirk Rider. Jack H. Harley as Boss Connelly. Walter Vaughn as Lambert. Don Briggs as Dr. Stanley Holton. Santos Ortega as Clint Morley. Lyle Sudrow as Mark Randall. John Larkin as Eric Watson. Cora B. Smith as Lili. Ginger Jones as Joan Ward. The annoucers were George Putman and Ron Rawson. Producer-Directors were Tom McDermott, Hoty Allen, Kirby Hawkes, Beverly Smith, Paul Knight, Don Cope, and Mark Goodson. The writers were Mona Kent and Hector Chevigny. The theme "Portia" by Lew White.